张明凯
讲师
办公室：化学楼219
邮箱：mingkai.zhang@imu.edu.cn
教育背景
2020年-2024年 江南大学食品学院，工学博士
2023年-2024年 西班牙国家研究委员会（CSIC）食品研究所，联合培养博士
2016年-2018年 南京农业大学食品科技学院，农学硕士
工作经历
2025年-至今 内蒙古大学化学化工学院，讲师
2018年-2020年 统一企业（中国）投资有限公司，研究员
学术兼职
Food & Medicine Homology、Food Wellness、Advanced Functional Foods等期刊青年编委
Critical Reviews in Food Science and Nutrition、Journal of Agricultural and Food Chemistry等期刊审稿人
研究领域
1. 蛋白质消化吸收特性
2. 基于生物信息学的生物活性肽靶向挖掘与高效鉴定
3. 基于分子模拟的生物活性肽构效关系研究
4. 食源性蛋白肽降血糖机制解析
研究项目
1. 国家留学基金委，国家建设高水平大学公派联合培养博士研究生项目，2023-2024，主持，结题
2. 内蒙古大学，2025年引进高层次人才科研启动金，2025 -2027，主持，在研
代表性成果
学术论文：
1. Zhang Mingkai, Zhang Hui*, Wang Xingguo, et al. Targeted discovery of pea protein-derived GLP-1-secreting peptides by CaSR activation-based molecular docking and their digestive stability. Food Chemistry 2025, 464 (Pt 1),141569. (中科院一区TOP, IF: 8.8)
2. Zhang Mingkai, Zhang Hui*, Wang Xingguo, et al. Virtual screening of GLP-1-secreting peptides from pea protein hydrolysates via Peptide Transporter 1 (PepT1) activation-based molecular docking. Journal of Agricultural and Food Chemistry 2024, 72(24),13646-13653. (中科院一区TOP, IF: 6.1)
3. Zhang Mingkai, Zhang Hui*, Wang Xingguo, et al. Pea protein hydrolysate stimulates GLP-1 secretion in NCI-H716 cells via simultaneously activating sensing receptors CaSR and PepT1. Food & Function 2024, 15(20), 10316-10322. (中科院一区TOP, IF: 5.1)
4. Zhang Mingkai, Zhang Hui*, Wang Xingguo, et al. Evaluating the in situ Insulinotropic effects of pea protein hydrolysates mediated by active GLP-1 via a 2D and dual-layered coculture cell model. Journal of Agricultural and Food Chemistry 2023, 71 (38), 14038-14045. (中科院一区TOP, IF: 6.1)
5. Zhang Mingkai, Zhang Hui*, Wang Xingguo, et al. Transepithelial transport of the bifunctional peptide IPYWTY indirectly induced insulin release mediated by active GLP-1. Journal of Agricultural and Food Chemistry 2023, 71 (34), 12749-12756. (中科院一区TOP, IF: 6.1)
6. Zhang Mingkai, Zhang Hui*, Wang Xingguo, et al. Identification of novel dipeptidyl peptidase-4 inhibitory peptides from pea proteins: a combined in silico and in vitro study. Food Bioscience 2023, 56, 103374. (中科院一区TOP, IF: 5.2)
7. Zhang Mingkai, Zhang Hui*, et al. Rapid screening of novel dipeptidyl peptidase-4 inhibitory peptides from pea (Pisum sativum L.) protein using peptidomics and molecular docking. Journal of Agricultural and Food Chemistry 2022, 70 (33), 10221-10228. (中科院一区TOP, IF: 6.1)
8. Zhang Mingkai, Wang Pei*, Gu Zhenxin*, et al. Microbial transglutaminase-modified protein network and its importance in enhancing the quality of high-fiber tofu with okara. Food Chemistry 2019, 289, 169-176. (中科院一区TOP, IF: 8.8)
9. Zhang Mingkai, Zhang Hui*, et al. Food-derived dipeptidyl peptidase IV inhibitory peptides: Production, identification, structure-activity relationship, and their potential role in glycemic regulation. Critical Reviews in Food Science and Nutrition 2022, 64(8), 2053-2075. (中科院一区TOP, IF: 11.2)
10. Zhang Mingkai, Zhang Hui*, Wang Xingguo, et al. The impacts and mechanisms of dietary proteins on glucose homeostasis and food intake: a pivotal role of gut hormones. Critical Reviews in Food Science and Nutrition 2023, 64(33), 12744-12758. (中科院一区TOP, IF: 10.2)
发明专利：
1) 张晖，张明凯，朱玲，一种豌豆蛋白源DPP-IV抑制肽及其筛选方法；公开：ZL 202210257157.7
2) 张晖，张明凯，朱玲，一种 Caco-2 + NCI-H716与Beta-TC-6 双层共培养细胞模型的构建方法及应用；实审：202310252890.4
3) 顾振新，张明凯，杨润强，王沛，一种小麦胚芽全豆豆腐生产方法；公开：CN201710820240.X
