胡日查

教授,博士生导师

办公室:化学楼205

电话:18047181136

邮箱:hbaigude@imu.edu.cn


教育背景

1987-1991内蒙古师范大学生物系读本科,获理学学士学位

1996-1999:内蒙古大学生命科学学院读硕士,获理学硕士学位

2001-2004:日本帝京科学大学环境与材料科学系读博士,获理学博士学位

 

工作经历

1999-2001:内蒙古大学化学化工学院讲师

2004-2005:日本北见工业大学做博士后研究

2005-2008:美国马萨诸塞州大学医学院做博士后研究

2008-2012:美国Sanford Burnham Prebys Medical Discovery Institute做博士后研究

2012至今:内蒙古大学化学化工学院教授

 

研究领域

1.      生物活性分子探针;

2.      生物大分子药物载体;

3.      蒙药研究作用机制;

 

教学

主讲化学化工学院大三《生物化学基础

 

研究项目

1.     国家自然科学基金面上项目,利用亲和光交联和纳米微粒检测microRNA靶基因的研究,2014/01-2017/12,主持;

2.     国家自然科学基金地区科学项目,利用分支多肽型纳米微粒靶向性传送siRNA的研究,2014/01-2017/12,主持;

3.     国家自然科学基金地区科学项目,降血脂活性天然产物荜茇宁特异性靶标的确定及其作用机理研究,2016/01-2019/12,主持;

4.     内蒙古自治区科技计划项目,额尔顿乌日勒和萨乌日勒对神经再生相关基因表达的调控作用研究,2015/01-2017/12,主要参与人;

5.     内蒙古自治区自然科学基金项目,萨乌日勒优化方对神经细胞的保护作用机理研究,2017/01-2019/12,主要参与人;

 

代表性成果

论文:

1.        Gerile Gerile, Tsogzolmaa Ganbold, Yizheng Li, and Huricha Baigude, Head group configuration increases biocompatibility of cationic lipids for nucleic acids delivery, Journal of Materials Chemistry B, 2017, 5: 5597-5607. (通讯作者)

2.        Yao Tong, Tsogzolmaa Ganbold, Huricha Baigude, Synthesis of Amphoteric Curdlan Derivatives for Delivery of Therapeutic Nucleic Acids, Carbohydrate Polymers, 2017, 175: 739-745. (通讯作者)

3.        Han J, Wang X, Liu L, Li D, Suyaola S, Wang T, Baigude H. "Click" chemistry mediated construction of cationic curdlan nanocarriers for efficient gene delivery. Carbohydr Polym. 2017, 163:191-198. (通讯作者)

4.        Tsogzolmaa Ganbold, Gerile Gerile, Hai Xiao and Huricha Baigude. Efficient in vivo siRNA delivery by stabilized D-peptide-based lipid nanoparticles. RSC Adv., 2017, 7, 8823-8831. (通讯作者)

5.        Xiule Hou, Tsogzolmaa Ganbold & Huricha Baigude. Synthesis of biocompatible amino acid-modified poly(acrylic acid) derivatives for intracellular gene delivery, International Journal of Polymeric Materials and Polymeric Biomaterials, 2017, 67:3, 174-180 (通讯作者)

6.        Altangerel A, Cai J, Liu L, Wu Y, Baigude H, Han J. PEGylation of 6-amino-6-deoxy curdlan for efficient in vivo siRNA delivery. Carbohydr Polym. 2016, 141:92-8. (通讯作者)

7.        Xiao H, Altangerel A, Gerile G, Wu Y, Baigude H. Design of Highly Potent Lipid-Functionalized Peptidomimetics for Efficient in Vivo siRNA Delivery. ACS Appl Mater Interfaces. 2016, 8(12):7638-45.(通讯作者)

8.        Yinga Wu, Jia Cai, Jingfen Han, Huricha Baigude. Cell Type-Specific Delivery of RNAi by Ligand-Functionalized Curdlan Nanoparticles: Balancing the Receptor Mediation and the Charge Motivation. ACS Appl Mater Interfaces. 2015, 7(38):21521-8.(通讯作者)

9.        Jingfen Han, Jia Cai, Wuyinga Borjihan, Tsogzolmaa Ganbold, Tariq M. Rana, Huricha Baigude(2015). Preparation of Novel Curdlan Nanoparticles for Intracellular siRNA Delivery. Carbohydrate Polymers, 117, 324–330.(通讯作者)

10.     Yu S, Gao X, Baigude H, Hai X, Zhang R, Gao X, Shen B, Li Z, Tan Z, Su H (2015). Inorganic nanovehicle for potential targeted drug delivery to tumor cells, tumor optical imaging. ACS Appl Mater Interfaces. 7(9):5089-96.

11.     McCarroll JA, Dwarte T, Baigude H, Dang J, Yang L, Erlich RB, Kimpton K, Teo J, Sagnella SM, Akerfeldt MC, Liu J, Phillips PA, Rana TM (2014), Kavallaris M.Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer. Oncotarget. 6(14):12020-34.

12.    Huricha Baigude, Tariq M. Rana (2014). Strategies to antagonize miRNA functions in vitro and in vivo. Nanomedicine (Lond), 9(16), 2545-55.

13.    Sarnaizul E, Borjihan G, Baigude H et al. (2013). LC analysis and pharmacokinetic study of synthetic piperlonguminine in rat plasma after oral administration. Biomed Chromatogr. 27(7), 821-4.

14.     Huricha Baigude, Jie Su, Joshua McCarroll, and Tariq M. Rana (2013). In Vivo Delivery of RNAi by Reducible Interfering Nanoparticles (iNOPs). ACS Med. Chem. Lett., DOI: 10.1021/ml4001003.

15.    Huricha Baigude, Ahsanullah, Zhonghan Li, Ying Zhou, and Tariq Rana (2012). miR-TRAP: a Benchtop Chemical Biology Strategy to Identify microRNA Targets. Angew. Chem. Int. Ed. 51, 5880 -5883.

16.     Huricha Baigude, Tariq Rana (2012). Interfering nanoparticles for microRNA delivery. Methods in Enzymology. 509, 339-53.

17.    Huricha Baigude*, Joshua McCarroll*, Chao-shun Yang, Tariq M. Rana (2010). Nanotubes Functionalized with Lipids and Natural Amino Acid Dendrimers: A New Strategy to Create Nanomaterials for Delivering Systemic RNAi.Bioconjugate Chem.21, 56-63.

18.     Huricha Baigude, Tariq M. Rana (2009). Delivery of Therapeutic RNAi by Nanovehicles. ChemBioChem10,2449-2454.

19.     Huricha Baigude, Joshua McCarroll, Chao-shun Yang, Pamela M. Swain, and Tariq M. Rana (2007). Design and Creation of New Nanomaterials for Therapeutic RNAi. ACS Chemical Biology, 2(4), 237-241.

20.    Huricha Baigude, Kaname Katsuraya, Shinichi Tokunaga, Naohiko Fujiwara, Masaya Satoyama, Tomohiro Magome, Kohsaku Okuyama, Gereltu Borjihan, Toshiyuki Uryu (2005). Synthesis of an oligosaccharide-polylysine dendrimer with reducing sugar terminals leading to acquired immunodeficiency syndrome vaccine preparation. J. Polym. Sci. A Polym. Chem., 43, 2195-2206.

21.    Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Naoki Kariya, and Toshiyuki Uryu (2004). Synthesis of HIV Vaccine Model Based on Lactose-Functionalized Poly(lysine) Dendrimer Scaffold. Sen’i Gakkaishi, 60, 118-124.

22.     Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Kenichi, Hatanaka, Emi Ikeda, Naokazu Shibata, and Toshiyuki Uryu (2004). Synthesis of Spherical and Hemispherical Sugar-Containing Poly(ornithine) Dendrimers. J. Polym. Sci. A Polym. Chem.,42, 1400-1414.

23.    Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, and Toshiyuki Uryu (2004). Synthesis of Structurally-Controlled HIV Vaccine Model Having Glyco-Peptide Dendrimer Scaffolds” Macromol. Chem. Phys., 205, 684-691.

24.     Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Shinichi Tokunaga, and Toshiyuki Uryu (2003). Synthesis of Sphere-Type Monodispersed Oligosaccharide Polypeptide Dendrimers. Macromolecules, 36, 7100-7106.

25.    Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Yoshihide Yachi, Shoma Sato, and Toshiyuki Uryu (2002). Synthesis of Dicarboxylate Oligosaccharide Multilayer Terminal Functionality upon Poly(lysine) Dendrimer Scaffolding. J. Polym. Sci. A Polym. Chem., 40, 3622-3633.

26.     Jie Su, Huricha Baigude, Joshua McCarroll and Tariq M. Rana (2011). Silencing microRNA by interfering nanoparticles in mice. Nucleic Acids Research, 39(6), e38, doi:10.1093/nar/gkq1307.

27.     Animesh Ghosh, Koushik Mukherjee, Xinpeng Jiang, Ying Zhou, Joshua McCarroll, James Qu, Pamela M. Swain, Huricha Baigude, and Tariq M. Rana (2010). Design and Assembly of New Nonviral RNAi Delivery Agents by Microwave-Assisted Quaternization (MAQ) of Tertiary Amines.Bioconjugate Chem.21 (9), 1581–1587.

28.     Hongyan Wang, Animesh Ghosh, Huricha Baigude, Chao-shun Yang, Linghua Qiu, Xugang Xia, Hongxia Zhou, Tariq M. Rana and Zuoshang Xu (2008). Therapeutic Gene Silencing Delivered by A Chemically Modified siRNA Against Mutant SOD1 Slows ALS Progression J. Biol. Chem., 283, 15845-15852.